Photothermal therapy (PTT) is a fledgling therapeutic strategy for cancer treatment with minimal invasiveness but clinical adoption has been stifled by concerns such as insufficient biodegradability of the PTT agents and lack of an efficient delivery system. Here, black phosphorus (BP) nanosheets are incorporated with a thermosensitive hydrogel [poly(d,l‐lactide)‐poly(ethylene glycol)‐poly(d,l‐lactide) (PDLLA‐PEG‐PDLLA: PLEL)] to produce a new PTT system for postoperative treatment of cancer. The BP@PLEL hydrogel exhibits excellent near infrared (NIR) photothermal performance and a rapid NIR‐induced sol–gel transition as well as good biodegradability and biocompatibility in vitro and in vivo. Based on these merits, an in vivo PTT postoperative treatment strategy is established. Under NIR irradiation, the sprayed BP@PLEL hydrogel enables rapid gelation forming a gelled membrane on wounds and offers high PTT efficacy to eliminate residual tumor tissues after tumor removal surgery. Furthermore, the good photothermal antibacterial performance prevents infection and this efficient and biodegradable PTT system is very promising in postoperative treatment of cancer.

中文翻译：

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黑磷掺入水凝胶作为可喷涂和可生物降解的光热平台，用于癌症术后治疗

光热疗法 (PTT) 是一种新兴的微创癌症治疗策略，但由于 PTT 药物生物降解性不足和缺乏有效的递送系统等问题，其临床应用受到阻碍。在这里，黑磷（BP）纳米片与热敏水凝胶[聚（d，l-丙交酯）-聚（乙二醇）-聚（d，l-丙交酯）（PDLLA-PEG-PDLLA：PLEL）]结合以产生用于癌症术后治疗的新型 PTT 系统。BP@PLEL水凝胶表现出优异的近红外（NIR）光热性能和快速NIR诱导的溶胶-凝胶转变，以及良好的体外和体内生物降解性和生物相容性。基于这些优点，建立了体内PTT术后治疗策略。在近红外辐射下，喷涂的BP@PLEL水凝胶能够快速凝胶化，在​​伤口上形成凝胶膜，并具有高PTT功效，可消除肿瘤切除手术后残留的肿瘤组织。此外，良好的光热抗菌性能可防止感染，这种高效且可生物降解的PTT系统在癌症术后治疗中非常有前景。