Hexavalent chromium [Cr(VI)] is a marine pollution of concern as recent studies show it has a global distribution, with some regions showing high Cr concentrations in marine animal tissue, and it is extensively used. Leatherback sea turtles (Dermochelys coriacea) are an endangered marine species that may experience prolonged exposures to environmental contaminants including Cr(VI). Human activities have led to global Cr(VI) contamination of the marine environment. While Cr(VI) has been identified as a known human carcinogen, the health effects in marine species are poorly understood. In this study, we assessed the cytotoxic and genotoxic effects of particulate and soluble Cr(VI) in leatherback sea turtle lung cells. Both particulate and soluble Cr(VI) induced a concentration-dependent increase in cytotoxicity. Next, using a chromosome aberration assay, we assessed the genotoxic effects of Cr(VI) in leatherback sea turtle lung cells. Particulate and soluble Cr(VI) induced a concentration-dependent increase in clastogenicity in leatherback sea turtle lung cells. These data indicate that Cr(VI) may be a health concern for leatherback sea turtles and other long-lived marine species. Additionally, these data provide foundational support to use leatherback sea turtles as a valuable model species for monitoring the health effects of Cr(VI) in the environment and possibly as an indicator species to assess environmental human exposures and effects.

中文翻译：

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棱皮海龟肺细胞中颗粒和可溶性六价铬的细胞毒性和遗传毒性。

六价铬[Cr（VI）]是引起人们关注的海洋污染，因为最近的研究表明六价铬具有全球分布，有些地区在海洋动物组织中显示出高的Cr浓度，因此被广泛使用。棱皮海龟（Dermochelys coriacea）是一种濒临灭绝的海洋物种，可能会长时间暴露于包括Cr（VI）在内的环境污染物中。人类活动已导致全球六价铬对海洋环境的污染。尽管六价铬已被确定为已知的人类致癌物，但对海洋物种的健康影响知之甚少。在这项研究中，我们评估了棱皮海龟肺细胞中微粒和可溶性Cr（VI）的细胞毒性和遗传毒性作用。颗粒状和可溶性Cr（VI）均可引起浓度依赖性的细胞毒性增加。下一个，使用染色体畸变分析，我们评估了棱皮海龟肺细胞中六价铬的遗传毒性作用。颗粒状和可溶性六价铬可诱导棱皮海龟肺细胞的致裂作用浓度依赖性增加。这些数据表明，Cr（VI）可能对棱皮海龟和其他长寿海洋物种具有健康影响。此外，这些数据为使用棱皮海龟作为监测环境中六价铬对健康的影响的有价值的典范物种提供了基础支持，并有可能作为评估人类环境暴露和影响的指示物种。这些数据表明，Cr（VI）可能对棱皮海龟和其他长寿海洋物种具有健康影响。此外，这些数据为使用棱皮海龟作为监测环境中六价铬对健康的影响的有价值的典范物种提供了基础支持，并有可能作为评估人类环境暴露和影响的指示物种。这些数据表明，Cr（VI）可能对棱皮海龟和其他长寿海洋物种具有健康影响。此外，这些数据为使用棱皮海龟作为监测环境中六价铬对健康的影响的有价值的典范物种提供了基础支持，并有可能作为评估人类环境暴露和影响的指示物种。