当前位置: X-MOL 学术Circulation › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
From the Literature
Circulation ( IF 37.8 ) Pub Date : 2018-03-06 , DOI: 10.1161/circulationaha.117.033410
Tracy Hampton

Researchers who previously developed a semisynthetic strain of the bacterium Escherichia coli with a genetic code containing 2 unnatural nucleotides in addition to the 4 natural nucleotides of DNA have now shown that the bacterium efficiently transcribes and translates both the natural and unnatural nucleotides to synthesize protein. The use of organisms to make nonnatural proteins, as demonstrated in this latest research published in Nature , may pave the way for scientists to engineer novel therapeutics or protein drugs, plastics, and other materials that take on new functions such as the ability to degrade pollutants or toxic molecules or to target and destroy specific tissues or cell types in the body. The research also offers new conceptual information that could change how scientists view biology. “Forever it has been argued that the molecules of life are somehow special and different from other types of molecules. This has often been based on religion, but also, the idea has remained common among scientists because it seems that biology is so complex and that evolution must have tailored them over billions of years,” said …

中文翻译:

来自文学

以前开发了具有半编码DNA的细菌的大肠杆菌的半合成菌株的研究人员,该遗传密码除DNA的4个天然核苷酸外还包含2个非天然核苷酸,现在表明该细菌可以有效转录并翻译天然和非天然核苷酸以合成蛋白质。正如发表在《自然》杂志上的最新研究所证明的那样,利用生物体制造非天然蛋白质可能为科学家设计新的疗法或蛋白质药物,塑料以及具有新功能(例如降解污染物的能力)的其他材料铺平道路。或有毒分子,或靶向并破坏体内的特定组织或细胞类型。这项研究还提供了新的概念性信息,这些信息可能会改变科学家对生物学的看法。“一直以来,人们一直争论着生命分子在某种程度上是特殊的,并且与其他类型的分子不同。这通常是基于宗教,但是,这一想法在科学家中仍然很普遍,因为它看起来生物学如此复杂,而且进化一定已经为他们量身定制了数十亿年的历史。”
更新日期:2018-03-06
down
wechat
bug