Rice bran oil (RBO) possesses a plasma cholesterol-lowering activity, while effect of wheat bran oil (WBO) on plasma cholesterol remains unknown. The present study compared the cholesterol-lowering activity of WBO with that of RBO in hamsters. Fifty-four male hamsters were divided into seven groups fed either a noncholesterol diet (NCD) or one of six high-cholesterol diets, namely HCD diet (0.2% cholesterol +9.5% lard), HCD+C diet (0.2% cholesterol +9.5% lard +0.5% cholestyramine), WL diet (0.2% cholesterol +4.8% Lard +4.8% WBO), WH diet (0.2% cholesterol +9.5% WBO), RL diet (0.2% cholesterol +4.8% Lard +4.8% RBO), and RH diet (0.2% cholesterol +9.5% RBO). Plasma total cholesterol (TC) in HCD group was 327.4 ± 31.8 mg/dL, while plasma TC in two WBO and two RBO groups was 242.2 ± 20.8, 243.1 ± 31.7, 257.1 ± 16.3, and 243.4 ± 46.0 mg/dL, respectively, leading to a decrease in plasma TC by 22–26% (P < 0.01). No significant difference in cholesterol-lowering potency was seen between WBO and RBO. Plasma cholesterol-lowering activity of WBO and RBO was accompanied by down-regulation of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase and fatty acid synthase, while up-regulation of cholesterol-7α-hydroxylase. WL, WH, RL, and RH diets increased the fecal excretion of total neutral sterols by 72.8%, 106.9%, 5.4%, and 36.8% (P < 0.01) respectively. Results indicated WBO and RBO could inhibit cholesterol absorption via down-regulation of intestinal Niemann-Pick C1 like 1 protein, acyl CoA:cholesterol acyltransferase 2, and ATP binding cassette transporter 5. In summary, WBO was equally effective as RBO in decreasing plasma cholesterol in hypercholesterolemia hamsters.

中文翻译：

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膳食麦麸油在减少血浆胆固醇方面与米糠油同样有效

米糠油（RBO）具有降低血浆胆固醇的活性，而麦麸油（WBO）对血浆胆固醇的作用仍然未知。本研究比较了仓鼠中WBO和RBO的胆固醇降低活性。54只雄性仓鼠分为7组，分别饲喂非胆固醇饮食（NCD）或六种高胆固醇饮食之一，即HCD饮食（0.2％胆固醇+ 9.5％猪油），HCD + C饮食（0.2％胆固醇+9.5） ％猪油+ 0.5％胆甾醇胺），WL饮食（0.2％胆固醇+ 4.8％猪油+ 4.8％WBO），WH饮食（0.2％胆固醇+ 9.5％WBO），RL饮食（0.2％胆固醇+ 4.8％猪油+ 4.8％RBO ）和RH饮食（0.2％胆固醇+ 9.5％RBO）。HCD组的血浆总胆固醇（TC）为327.4±31.8 mg / dL，两个WBO和两个RBO组的血浆TC为242.2±20.8、243.1±31.7、257.1±16.3和243.4±46.0 mg / dL，P <0.01）。在WBO和RBO之间，降低胆固醇的能力没有显着差异。WBO和RBO的血浆胆固醇降低活性伴随着肝3-羟基-3-甲基戊二酰辅酶A还原酶和脂肪酸合酶的下调，而胆固醇-7α-羟化酶的上调。WL，WH，RL和RH饮食分别使总中性固醇的粪便排泄量增加72.8％，106.9％，5.4％和36.8％（P <0.01）。结果表明，WBO和RBO可以通过下调肠道Niemann-Pick C1样蛋白1，酰基CoA：胆固醇酰基转移酶2和ATP结合盒转运蛋白5来抑制胆固醇吸收。总之，WBO与RBO在降低血浆胆固醇方面同样有效在高胆固醇血症仓鼠中。