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A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications
Bioconjugate Chemistry ( IF 4.7 ) Pub Date : 2018-03-02 00:00:00 , DOI: 10.1021/acs.bioconjchem.7b00821
Haihong He 1 , Yang Xia 1 , Yingxue Qi 1 , Hong-Yin Wang 2 , Zhuang Wang 1 , Jianming Bao 3 , Ziqian Zhang 4 , Fu-Gen Wu 2 , Haolu Wang 5 , Daijie Chen 6 , Dahai Yang 1 , Xiaowen Liang 5 , Jinquan Chen 7 , Shengmin Zhou 1 , Xin Liang 1 , Xuhong Qian 1 , Youjun Yang 1
Affiliation  

Nitric oxide (NO) is a versatile endogenous molecule, involved in various physiological processes and implicated in the progression of many pathological conditions. Therefore, NO donors are valuable tools in NO related basic and applied applications. The traditional spontaneous NO donors are limited in scenarios where flux, localization, and dose of NO could be monitored. This has promoted the development of novel NO donors, whose NO release is not only under control, but also self-calibrated. Herein, we reported a phototriggered and photocalibrated NO donor (NOD565) with an N-nitroso group on a rhodamine dye. NOD565 is nonfluorescent and could release NO efficiently upon irradiation by green light. A bright rhodamine dye is generated as a side-product and its fluorescence can be used to monitor the NO release. The potentials of NOD565 in practical applications are showcased in in vitro studies, e.g., platelet aggregation inhibition and fungi growth suppression.

中文翻译:

用于生物应用的水溶性,绿光触发和光校准的一氧化氮供体

一氧化氮(NO)是一种通用的内源性分子,参与各种生理过程,并涉及许多病理状况的进展。因此,在没有相关的基础和应用中,没有捐助者是有价值的工具。传统的自发NO供体在可以监测NO的通量,位置和剂量的情况下受到限制。这促进了新型NO供体的开发,其NO释放不仅在控制范围内,而且还可以自我校准。在本文中,我们报道了在罗丹明染料上具有N-亚硝基的光触发和光校准的NO供体(NOD565)。NOD565是非荧光性的,在绿光照射下可以有效释放NO。生成光亮的罗丹明染料作为副产物,其荧光可用于监测NO的释放。在体外研究中展示了NOD565在实际应用中的潜力,例如,血小板聚集抑制和真菌生长抑制。
更新日期:2018-03-02
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