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Self-Assembly of Triblock Copolymers from Cyclic Esters as a Tool for Tuning Their Particle Morphology
Langmuir ( IF 3.9 ) Pub Date : 2018-03-02 00:00:00 , DOI: 10.1021/acs.langmuir.8b00440
M. Socka 1 , M. Brzezinski 1 , A. Michalski 1 , A. Kacprzak 1 , T. Makowski 1 , A. Duda 1
Affiliation  

This paper presents the effect of end groups, chain structure, and stereocomplexation on the microparticle and nanoparticle morphology and thermal properties of the supramolecular triblock copolyesters. Therefore, the series of the triblock copolymers composed of l,l- and d,d-lactide, trimethylene carbonate (TMC), and ε-caprolactone (CL) with isopropyl (iPr) or 2-ureido-4-[1H]-pyrimidinone (UPy) end groups at both chain ends were synthesized. In addition, these copolymers were intermoleculary stereocomplexed by polylactide (PLA) blocks with an opposite configuration of repeating units to promote their self-assembly in various organic solvents. The combination of two noncovalent interactions of the end groups and PLA enantiomeric chains leads to stronger interactions between macromolecules and allows for alteration of their segmental mobility. The simple tuning of the copolymer microstructure and functionality induced the self-assembly of macromolecules at liquid/liquid interfaces, which consequently leads to their phase separation in the form of particles with diameters ranging from 0.1 μm to 10 μm. This control is essential for their potential applications in the biomedical field, where biocompatible and well-defined microparticles and nanoparticles are highly desirable.

中文翻译:

环酯三嵌段共聚物的自组装作为调节其颗粒形态的工具

本文介绍了端基,链结构和立体复杂化对超分子三嵌段共聚酯的微粒和纳米粒子的形态和热性能的影响。因此,由l,l-d,d-丙交酯,碳酸三亚甲基酯(TMC)和ε-己内酯(CL)与异丙基(i Pr)或2-脲基-4- [1 H]组成的三嵌段共聚物系列合成了在两个链端的]-嘧啶酮(UPy)端基。另外,这些共聚物在分子间被聚丙交酯(PLA)嵌段立体复合,并具有相反的重复单元构型,以促进它们在各种有机溶剂中的自组装。端基和PLA对映体链的两个非共价相互作用的组合导致大分子之间更强的相互作用,并允许其节段迁移率发生变化。共聚物微结构和官能度的简单调节引起大分子在液/液界面处的自组装,因此导致它们以直径范围从0.1μm到10μm的颗粒形式发生相分离。这种控制对于它们在生物医学领域的潜在应用至关重要,
更新日期:2018-03-02
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