Aronia berries are rich in polyphenols with anti-inflammatory activity. We hypothesized that aronia berry consumption modulates intestinal immune function and T cells. The aims of the present work were to assess the immunomodulatory potential of ‘Viking’ aronia berry (black chokeberry, Aronia mitschurinii) in vivo and to determine the extent aronia berry polyphenols or known microbial polyphenol catabolites inhibit T cell tumour necrosis factor (TNF)-α in vitro. Aronia berry consumption increased colonic IL-10 secretion in healthy mice, but did not inhibit ex vivo cytokine secretion of lipopolysaccharide-stimulated spleen and colon tissue. Aronia berry consumption inhibited wasting associated with T cell adoptive transfer and dextran sulphate sodium induced colitis. Aronia extracts, neutral phenols fraction, and the polyphenol catabolites 3,4-dihydroxyphenylacetic acid and 3,4-dihydroxyphenylpropionic acid inhibited TNF-α production in Jurkat T cells. Therefore, T cells and microbial catabolism partly mediate the anti-inflammatory effects of aronia consumption in the colon.

Aronia浆果富含具有抗炎活性的多酚。我们假设食用无花果浆果可以调节肠道免疫功能和T细胞。本工作的目的是评估Viking'Aronia berry（黑苦莓，Aronia mitschurinii）在体内的免疫调节潜力，并确定Aronia berry多酚或已知的微生物多酚分解代谢物抑制T细胞肿瘤坏死因子（TNF）的程度- α体外。食用无花果浆果可增加健康小鼠结肠IL-10的分泌，但不能抑制离体脂多糖刺激的脾脏和结肠组织的细胞因子分泌。阿罗尼亚浆果的食用抑制了与T细胞过继转移和右旋糖酐硫酸钠引起的结肠炎有关的浪费。Aronia提取物，中性酚类成分和多酚分解代谢产物3,4-二羟基苯基乙酸和3,4-二羟基苯基丙酸抑制Jurkat T细胞中TNF-α的产生。因此，T细胞和微生物的分解代谢部分介导了结肠中消耗有氧植物的抗炎作用。