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Bio-inspired drug delivery systems: an emerging platform for targeted cancer therapy
Biomaterials Science ( IF 6.6 ) Pub Date : 2018-03-02 00:00:00 , DOI: 10.1039/c8bm00175h
Gella Maelys Ngandeu Neubi 1, 2, 3, 4, 5 , Yaw Opoku-Damoah 1, 2, 3, 4, 5 , Xiaochen Gu 6, 7, 8, 9 , Yue Han 1, 2, 3, 4, 5 , Jianping Zhou 1, 2, 3, 4, 5 , Yang Ding 1, 2, 3, 4, 5
Affiliation  

The quest for an ideal cancer treatment has led to the exploration of a variety of platforms to facilitate highly desirable and efficient drug delivery. As most anticancer drugs possess therapeutic potency to destroy tumor cells, there is a need to steer the compounds to their required sites using site-specific drug delivery vehicles. This has inspired the investigation of various natural particulates and biomaterials for the purpose. Bio-inspired platforms that directly mimic natural components in the body have demonstrated their ability to serve as one of the most versatile and innovative drug delivery systems in cancer therapy and diagnosis. The primary advantage of this innovation lies in the fundamental changes in systemic biodistribution that non-native drug delivery does not possess. This review will try to provide a comprehensive understanding and a succinct evaluation of various intelligent bio-inspired delivery platforms, which have become prominent in recent studies. Recent innovative examples and their advantages and limitations as well as future clinical potential will also be thoroughly discussed.

中文翻译:

受生物启发的药物输送系统:靶向癌症治疗的新兴平台

对理想癌症治疗的追求导致探索各种平台以促进高度期望和有效的药物递送。由于大多数抗癌药物具有破坏肿瘤细胞的治疗潜能,因此需要使用位点特异性药物递送载体将化合物引导至其所需位点。为此激发了对各种天然微粒和生物材料的研究。直接模仿人体中自然成分的受生物启发的平台已显示出它们具有成为癌症治疗和诊断中最通用,最创新的药物输送系统之一的能力。这项创新的主要优势在于非原生药物递送所不具备的全身性生物分布的根本变化。这篇综述将试图提供对各种智能生物启发性递送平台的全面理解和简洁评估,这些在最近的研究中已变得十分突出。最近的创新实例及其优势和局限性以及未来的临床潜力也将被彻底讨论。
更新日期:2018-03-02
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