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Facile Synthesis of Single α‐tert‐Alkylated Acetaldehydes by Hydroxyalkylation of Enamides in Aqueous Solution
Chemistry - A European Journal ( IF 4.3 ) Pub Date : 2018-04-06 , DOI: 10.1002/chem.201801065
Yumi Murata 1 , Takashi Nishikata 1
Affiliation  

In this work, we established a general protocol to synthesize single α‐tert‐alkylated acetaldehydes via Cu‐catalyzed hydroxyalkylation of enamides in aqueous solutions. The yields of the products were very high and there was excellent functional group compatibility. Our reaction allows easy access to highly functionalized acetaldehydes that can be used to synthesize further useful compounds including spirocycles. The control experiments revealed that this reaction includes hydroxyalkylation processes via radical reactions.

中文翻译:

水溶液中酰胺的羟烷基化反应可轻松合成单个α-叔烷基化乙醛

在这项工作中,我们建立了通用协议,通过水溶液中酰胺的铜催化羟烷基化来合成单个α-烷基化乙醛。产品的产率非常高,并且具有优异的官能团相容性。我们的反应可轻松获得高度官能化的乙醛,该乙醛可用于合成其他有用的化合物,包括螺环。对照实验表明,该反应包括通过自由基反应的羟烷基化过程。
更新日期:2018-04-06
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