In addition to being recognized as a chronic inflammatory disease that manifests in the skin, psoriasis is increasingly understood to be a systemic disease that causes immune dysregulation throughout the body. The systemic nature of psoriasis is evidenced by the higher burden of comorbidities and shorter life expectancies of patients with psoriasis, particularly those with early-onset and severe disease. Notably, psoriasis is associated with an increased risk for cardiovascular disease, which is the most common cause of morbidity and mortality in patients with psoriasis. In this review, we examine the association between psoriasis and cardiovascular disease and specifically focus on the role of interleukin 17–mediated inflammation as a potential mechanistic link between psoriasis and cardiovascular disease. Moreover, we describe potential treatment approaches to reduce the burden of cardiovascular disease in patients with psoriasis and discuss the clinical importance of the association of these 2 diseases with respect to patient management and education.

除了被认为是一种在皮肤上表现出来的慢性炎症性疾病外，牛皮癣也被越来越多地理解为一种全身性疾病，会引起全身免疫功能异常。牛皮癣的全身性特征由合并症的较高负担和较短的银屑病患者的预期寿命证明，特别是那些患有早发和严重疾病的患者。值得注意的是，牛皮癣与心血管疾病的风险增加有关，而心血管疾病是牛皮癣患者发病和死亡的最常见原因。在这篇综述中，我们研究了牛皮癣和心血管疾病之间的关联，并特别关注白介素17介导的炎症作为牛皮癣和心血管疾病之间潜在的机制联系的作用。而且，