Background

Vitiligo is a chronic autoimmune skin disorder affecting 1% of populations worldwide. Few large-scale studies have explored adverse pregnancy outcomes in patients with vitiligo.

Objective

To investigate adverse pregnancy outcomes in patients with vitiligo.

Methods

We performed a retrospective cohort study on 4738 pregnancies of women with vitiligo and 47,380 pregnancies of age-matched controls without vitiligo using the Korean National Health Insurance Claims database from 2007 to 2016. Multivariate logistic regression models were used to evaluate the associations between vitiligo and pregnancy outcomes, including live births, spontaneous abortion, cesarean delivery, preterm delivery, gestational diabetes mellitus, stillbirth, pre-eclampsia/eclampsia, and intrauterine growth retardation.

Results

Patients with vitiligo exhibited a significantly lower live birth rate (odds ratio, 0.870; 95% confidence interval, 0.816-0.927) and a higher incidence of spontaneous abortion (odds ratio, 1.250; 95% confidence interval, 1.148-1.362) than the control group.

Limitation

The Korean National Health Insurance Claims database lacks detailed clinical information on individual patients.

Conclusion

Vitiligo was significantly associated with an increased risk of spontaneous abortion. Further studies are needed to determine whether systemic autoimmunity explains our finding.

中文翻译：

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白癜风患者的妊娠结局：韩国一项基于人群的全国队列研究

背景

白癜风是一种慢性自身免疫性皮肤病，影响全世界1％的人口。很少有大规模研究探讨白癜风患者的不良妊娠结局。

客观的

调查白癜风患者的不良妊娠结局。

方法

我们使用2007年至2016年的韩国国家健康保险理赔数据库，对4738例白癜风孕妇和47380例无白癜风的对照组孕妇进行了回顾性队列研究。多因素Logistic回归模型用于评估白癜风与妊娠之间的关联结果，包括活产，自然流产，剖宫产，早产，妊娠糖尿病，死产，先兆子痫/子痫和子宫内发育迟缓。

结果

白癜风患者的活产率（比值比为0.870; 95％的置信区间为0.816-0.927）和自然流产的发生率（比值是1.250; 95％的置信区间为1.148-1.362）团体。

局限性

韩国国民健康保险理赔数据库缺乏有关个别患者的详细临床信息。

结论

白癜风与自然流产风险增加显着相关。需要进一步研究以确定全身自身免疫是否可以解释我们的发现。