In a recent article in Cell Reports, Dalby and colleagues convincingly demonstrate that choosing an inadequate control diet in animal experiments that investigate the interaction of nutrition, gut microbiota, and obesity development may lead to the wrong conclusions. The authors systematically compared the effects of refined high- and low-fat diets (rHFD and rLFD) with those of a standard chow diet on mouse physiology, microbiota composition, cecal fermentation, and intestinal morphology. The results obtained in this study question the conclusions drawn from animal studies that compared the effects of HFDs with those of chow diets.

中文翻译：

---

我们是否明智地选择控制饮食？

在最近发表在 Cell Reports 上的一篇文章中，Dalby 及其同事令人信服地证明，在研究营养、肠道微生物群和肥胖发展之间相互作用的动物实验中，选择不适当的控制饮食可能会导致错误的结论。作者系统地比较了精制高脂和低脂饮食（rHFD 和 rLFD）与标准食物对小鼠生理、微生物群组成、盲肠发酵和肠道形态的影响。本研究中获得的结果对动物研究得出的结论提出了质疑，这些研究比较了 HFDs 与饲料的影响。