Original citation: J Clin Invest. 2014;124(5):2009–2022. https://doi.org/10.1172/JCI71951

Citation for this corrigendum: J Clin Invest. 2018;128(3):1200–1201. https://doi.org/10.1172/JCI120358

The Editors recently posted an Expression of Concern for this article due to duplication of some of the flow cytometry plots in Figures 5C and 7A (1). The authors have completed three replicate experiments for the panels in question, and the updated findings appear below. The revised experiments were conducted by Yaniv Zohar, and the analysis was completed independently in a blinded fashion. The authors report in Figure 5C that repeated administration of CXCL11-Ig increased the in vivo polarization of IL-10^hi CD4⁺ T cells, suggesting that CXCL11 supports Tr1 polarization. In addition, the authors state that Experiments 1 and 2 suggest that the administration of CXCL10-Ig induced IFN^hi Th1 cells, consistent with the notion of the differential functions of CXCL10 and CXCL11 in T cell polarization. This finding was not confirmed in Experiment 3.

Figure 7A shows reduced accumulation of injected CD4⁺ T cells in the draining LN and spinal cord, but not the spleen, consistent with the original findings of the article.

The authors regret the errors and appreciate the opportunity to correct the article.

1. J Clin Invest. 2017;127(10):3913. https://doi.org/10.1172/JCI97015

Footnotes

See the related article at CXCL11-dependent induction of FOXP3-negative regulatory T cells suppresses autoimmune encephalomyelitis.

原始引文：J Clin Invest。2014; 124（5）：2009-2022。https://doi.org/10.1172/JCI71951

该勘误的引文：J Clin Invest。2018; 128（3）：1200–1201。https://doi.org/10.1172/JCI120358

由于重复了图5C和7A（1）中的某些流式细胞仪图，因此编辑最近在本文中发表了关注的表达。作者已经完成了有关面板的三个重复实验，更新的发现如下所示。修改后的实验由Yaniv Zohar进行，分析以盲目方式独立完成。作者在图5C中报告，重复施用CXCL11-Ig可增加IL-10 ^hi CD4 ⁺ T细胞的体内极化，表明CXCL11支持Tr1极化。此外，作者指出，实验1和2表明，施用CXCL10-Ig会诱导IFN ^hiTh1细胞，与T细胞极化中CXCL10和CXCL11的微分功能的概念一致。实验3未确认此发现。

图7A显示，在引流的LN和脊髓中，但在脾脏中，注射的CD4 ⁺ T细胞积累减少，这与本文的原始发现是一致的。

作者对这些错误表示遗憾，并感谢有机会更正本文。

1. J Clin投资。2017; 127（10）：3913。https://doi.org/10.1172/JCI97015

脚注

请参阅相关文章，了解FOXP3负调节性T细胞的CXCL11依赖性诱导抑制自身免疫性脑脊髓炎。