Wound healing response plays a central part in chronic inflammation, affecting millions of people worldwide. It is a dynamic process that can lead to fibrosis, if tissue damage is irreversible and wound resolution is not attained. It is clear that there is a tight interconnection among wound healing, fibrosis and a variety of chronic disease conditions, demonstrating the heterogeneity of this pathology. Based on our further understanding of the cellular and molecular mechanisms underpinning tissue repair, new therapeutic approaches have recently been developed that target different aspects of the wound healing process and fibrosis. Nevertheless, several issues still need to be taken into consideration when designing modern wound healing drug delivery formulations. In this review, we highlight novel pharmacological agents that hold promise for targeting wound repair and fibrosis. We also focus on drug-delivery systems that may enhance current and future therapies.

伤口愈合反应在慢性炎症中起着核心作用，影响着全球数百万人。如果组织损伤不可逆且无法达到伤口愈合，则这是一个动态过程，可导致纤维化。显然，伤口愈合，纤维化和各种慢性疾病之间存在紧密的联系，这证明了这种病理学的异质性。基于我们对支撑组织修复的细胞和分子机制的进一步了解，最近开发了针对伤口愈合过程和纤维化的不同方面的新治疗方法。然而，在设计现代伤口愈合药物递送制剂时仍需要考虑几个问题。在这篇评论中，我们重点介绍了有望针对伤口修复和纤维化的新型药理剂。我们还将重点放在可以增强当前和未来疗法的药物输送系统上。