Fatty acid drug discovery (FADD) is defined as the identification of novel, specialized bioactive mediators that are derived from fatty acids and have precise pharmacological/therapeutic potential. A number of reports indicate that dietary intake of omega-3 fatty acids and limited intake of omega-6 promotes overall health benefits. In 1929, Burr and Burr indicated the significant role of essential fatty acids for survival and functional health of many organs. In reference to specific dietary benefits of differential omega-3 fatty acids, docosahexaenoic and eicosapentaenoic acids (DHA and EPA) are transformed to monohydroxy, dihydroxy, trihydroxy, and other complex mediators during infection, injury, and exercise to resolve inflammation. The presented FADD approach describes the metabolic transformation of DHA and EPA in response to injury, infection, and exercise to govern uncontrolled inflammation. Metabolic transformation of DHA and EPA into a number of pro-resolving molecules exemplifies a novel, inexpensive approach compared to traditional, expensive drug discovery. DHA and EPA have been recommended for prevention of cardiovascular disease since 1970. Therefore, the FADD approach is relevant to cardiovascular disease and resolution of inflammation in many injury models. Future research demands identification of novel action targets, receptors for biomolecules, mechanism(s), and drug-interactions with resolvins in order to maintain homeostasis.

脂肪酸药物发现（FADD）的定义是鉴定衍生自脂肪酸并具有精确药理/治疗潜力的新型专门生物活性介体。许多报告表明，饮食中摄入omega-3脂肪酸和限量摄入omega-6可以促进整体健康。1929年，Burr和Burr指出，必需脂肪酸对于许多器官的生存和功能健康具有重要作用。关于差异性ω3脂肪酸的特定饮食益处，二十二碳六烯酸和二十碳五烯酸（DHA和EPA）在感染，损伤和运动期间被转化为单羟基，二羟基，三羟基和其他复杂介质，以解决炎症。提出的FADD方法描述了DHA和EPA对伤害的代谢转化，感染，并进行锻炼以控制不受控制的炎症。与传统的昂贵药物发现相比，DHA和EPA代谢转化为许多促解析分子代表了一种新颖，廉价的方法。自1970年以来，就一直建议使用DHA和EPA预防心血管疾病。因此，在许多损伤模型中，FADD方法与心血管疾病和炎症的消退有关。未来的研究要求鉴定新的作用靶标，生物分子的受体，机制以及与分辨溶剂的药物相互作用，以维持体内稳态。自1970年以来，就一直建议使用DHA和EPA预防心血管疾病。因此，在许多损伤模型中，FADD方法与心血管疾病和炎症的消退有关。未来的研究要求鉴定新的作用靶标，生物分子的受体，机制以及与分辨溶剂的药物相互作用，以维持体内稳态。自1970年以来，就一直建议使用DHA和EPA预防心血管疾病。因此，在许多损伤模型中，FADD方法与心血管疾病和炎症的消退有关。未来的研究要求鉴定新的作用靶标，生物分子的受体，机制以及与分辨溶剂的药物相互作用，以维持体内稳态。