De novo sequence-level surveys of transcriptomes have previously relied on sequencing via a DNA intermediate. While such methods can yield massive data sets, various problems mean that these do not always accurately reflect the true innate composition of transcriptomes. Enter Garalde et al., who present for the first time highly parallel native RNA-Sequencing (RNA-seq), with potentially disruptive future-implications for the transcriptomics field.

中文翻译：

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天然RNA测序技术将其带入转录组学环

转录组的从头序列水平调查以前依赖于通过DNA中间体进行测序。尽管此类方法可以产生大量数据集，但各种问题意味着这些方法并不总是能够准确反映出转录组的真正固有组成。输入Garalde等人，他们首次展示了高度平行的天然RNA测序（RNA-seq），对转录组学领域具有潜在的破坏性未来意义。