Molecular imaging is critical to personalized and precision medicine. Although singly targeted imaging probes are making an impact both clinically and preclinically, molecular imaging strategies using bispecific probes have enabled improved visualization of cancer in recent years through synergistic targeting of two ligands. In this Focus on Molecular Imaging review, we outline how peptide-, antibody-, and nanoparticle-based platforms have affected this emerging strategy, providing examples and pointing out areas in which the greatest clinical impact may be realized.

中文翻译：

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癌症的双靶分子成像

分子成像对于个性化和精密医学至关重要。尽管单独靶向的成像探针在临床和临床前均产生影响，但近年来，使用双特异性探针的分子成像策略通过协同靶向两个配体，使得癌症的可视化得以改善。在本《聚焦分子成像》的综述中，我们概述了基于肽，抗体和纳米颗粒的平台如何影响这一新兴战略，提供了实例并指出了可以实现最大临床影响的领域。