Base-controlled chemoselectivity reaction of vinylanilines with isothiocyanates for synthesis of quinolino-2-thione and 2-aminoquinoline derivatives†,Chemical Communications

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Base-controlled chemoselectivity reaction of vinylanilines with isothiocyanates for synthesis of quinolino-2-thione and 2-aminoquinoline derivatives†
Chemical Communications ( IF 4.9 ) Pub Date : 2018-03-01 00:00:00 , DOI: 10.1039/c8cc00062j
Xi Zhang _{1,

2,

3,

4,

5} , Tong-Lin Wang _{1,

2,

3,

4,

5} , Cong-De Huo _{1,

2,

3,

4,

5} , Xi-Cun Wang _{1,

2,

3,

4,

5} , Zheng-Jun Quan _{1,

2,

3,

4,

5}

Affiliation

Here, we report a base-controlled chemo-selective reaction of vinylanilines with alkyl/aryl isothiocyanates to afford quinolino-2-thione and 2-aminoquinoline derivatives. The quinolino-2-thiones could be obtained in high yields in the presence of Et₃N. Particularly interesting is that the reaction could produce the 2-aminoquinolines in the presence of K₃PO₄ with high selectivity.

中文翻译：

乙烯基苯胺与异硫氰酸酯的碱控制化学选择性反应，用于合成喹啉基-2-硫酮和2-氨基喹啉衍生物†

在这里，我们报告乙烯基苯胺与烷基/芳基异硫氰酸酯的碱控制化学选择性反应，以提供喹啉基-2-硫酮和2-氨基喹啉衍生物。在Et ₃ N存在下，可以高产率获得喹啉-2--2-硫酮。特别有趣的是，在K ₃ PO ₄存在下，该反应可以产生2-氨基喹啉，具有高选择性。

更新日期：2018-03-01

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