INTRODUCTION: According to the “glymphatic system” hypothesis, brain waste clearance is mediated by a continuous replacement of the interstitial milieu by a bulk flow of cerebrospinal fluid (CSF). Previous reports suggested that this cerebral CSF circulation is only active during general anesthesia or sleep, an effect mediated by the dilatation of the extracellular space. Given the controversies regarding the plausibility of this phenomenon and the limitations of currently available methods to image the glymphatic system, we developed original whole-brain in vivo imaging methods to investigate the effects of general anesthesia on the brain CSF circulation.

中文翻译：

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全身麻醉抑制“淋巴系统”的活动

简介：根据“淋巴系统”假说，脑废物清除是由脑脊液（CSF）的大量流动连续替代间质环境所介导的。先前的报道表明，这种脑CSF循环仅在全身麻醉或睡眠期间才起作用，这种作用是由细胞外空间的扩张介导的。考虑到有关这种现象的合理性的争议以及目前可用的对淋巴系统成像的方法的局限性，我们开发了原始的全脑体内成像方法来研究全身麻醉对脑CSF循环的影响。