Background: Tumor cells require proficient autophagy to meet high metabolic demands and resist chemotherapy, which suggests that reducing autophagic flux might be an attractive route for cancer therapy. However, this theory in clinical cancer research remains controversial due to the limited number of drugs that specifically inhibit autophagy-related (ATG) proteins.

中文翻译：

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药物重筛选筛选确定噻康唑为ATG4抑制剂，该抑制剂可抑制自噬并能使癌细胞对化学疗法敏感。

背景：肿瘤细胞需要熟练的自噬来满足高代谢需求并抵抗化学疗法，这表明减少自噬通量可能是癌症治疗的诱人途径。但是，由于特异性抑制自噬相关蛋白（ATG）的药物数量有限，因此该理论在临床癌症研究中仍存在争议。