Described here is a reductive amination/hydrosilylation cascade of α,β‐unsaturated aldehydes mediated by a Lewis acidic borane catalyst. The present reaction system provides an one‐pot synthetic route towards β‐silylated secondary amines that have not been accessible by other previous catalysis. Comparative ¹H NMR studies on the silylative reduction of enimines revealed that steric bulkiness of primary amine reactants strongly affects both catalytic efficiency and regioselectivity. This strategy was applicable to a broad range of substrates and amenable to one‐pot gram‐scale synthesis. Moreover, a diastereoselective introduction of the β‐silyl group was also found to be feasible (d.r. up to 71:29).

中文翻译：

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α，β-不饱和醛的甲硅烷基化还原胺化反应：合成β-甲硅烷基化仲胺的简便方法

这里描述的是路易斯酸性硼烷催化剂介导的α，β-不饱和醛的还原胺化/氢化硅烷化级联。本反应系统提供了一种单罐合成路线，可通往其他先前催化无法达到的β-甲硅烷基化仲胺。对亚胺的甲硅烷基化还原进行的比较¹ H NMR研究表明，伯胺反应物的空间体积极大地影响了催化效率和区域选择性。该策略适用于广泛的底物，并适用于一锅克级合成。此外，还发现非对映选择性地引入β-甲硅烷基是可行的（dr高达71:29）。