The development of bioscaffolds that incorporate chondroitin sulphate (CS) and their applications with progenitor and stem cells in cartilage, bone, cornea, skin, and neural repair are reviewed. CS is a heterogeneous structure due to the organisation of multiple CS disaccharide sulphation motifs, giving rise to a vast range of CS chain structures, and hence the wide range of biological activity. The incorporation of this biological molecule represents a significant advance in bioscaffold design and performance in tissue repair strategies. The intrinsic stem-cell directive properties of CS are covered in the context of tissue development, and the differing CS disaccharide motifs, referred to as the ‘glyco-code’. These structural motifs contribute to stem cell proliferation and differentiation in the scaffold environment and improve outcomes in terms of tissue repair or regeneration worthy of future research.

中文翻译：

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利用复合支架中的硫酸软骨素指导祖细胞和干细胞的功能进行组织修复

综述了结合硫酸软骨素（CS）的生物支架的开发及其与祖细胞和干细胞在软骨，骨骼，角膜，皮肤和神经修复中的应用。由于多个CS二糖硫酸化基序的组织，CS是异质结构，从而产生了广泛的CS链结构，因此具有广泛的生物学活性。该生物分子的掺入代表了生物支架设计和组织修复策略中的性能的重大进步。CS的固有干细胞定向特性涵盖在组织发育的背景下，以及不同的CS二糖基序，也称为“糖基代码”。