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Organocatalytic reductive coupling of aldehydes with 1,1-diarylethylenes using an in situ generated pyridine-boryl radical†
Chemical Science ( IF 8.4 ) Pub Date : 2018-02-28 00:00:00 , DOI: 10.1039/c7sc05225a
Jia Cao 1, 2 , Guoqiang Wang 1 , Liuzhou Gao 1 , Xu Cheng 3 , Shuhua Li 1
Affiliation  

A pyridine-boryl radical promoted reductive coupling reaction of aldehydes with 1,1-diarylethylenes has been established via a combination of computational and experimental studies. Density functional theory calculations and control experiments suggest that the ketyl radical from the addition of the pyridine-boryl radical to aldehydes is the key intermediate for this C–C bond formation reaction. This metal-free reductive coupling reaction features a broad substrate scope and good functional compatibility.

中文翻译:

醛与 1,1-二芳基乙烯使用原位产生的吡啶-硼基自由基进行有机催化还原偶联†

通过计算和实验研究的结合,已经建立了促进醛与 1,1-二芳基乙烯的还原偶联反应的吡啶-硼基自由基。密度泛函理论计算和控制实验表明,将吡啶-硼基自由基加成到醛中的酮基自由基是该 C-C 键形成反应的关键中间体。这种无金属还原偶联反应具有广泛的底物范围和良好的功能相容性。
更新日期:2018-02-28
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