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Advances in glycosylation-mediated cancer-targeted drug delivery
Drug Discovery Today ( IF 7.4 ) Pub Date : 2018-02-28 , DOI: 10.1016/j.drudis.2018.02.009
Lulu Cai , Zhipeng Gu , Jian Zhong , Di Wen , Guojun Chen , Lin He , Jun Wu , Zhen Gu

Targeted drug delivery for cancer therapy is expected to enhance therapeutic efficacy with minimized side effects, where the ligand-receptor recognition serves as a common targeting approach. Various ligands have been reported and carbohydrates, one of the crucial structures of tumor cell membranes, have been demonstrated effective for cell-selective binding. Hence, glycosylation-mediated cancer-targeted drug nanocarriers have received increasing attention in recent years. This review surveys a variety of glycosylated drug delivery systems as well as their applications for cancer therapy. Their challenges, opportunities, and future perspectives are also discussed in the end.



中文翻译:

糖基化介导的癌症靶向药物的研究进展

预期用于癌症治疗的靶向药物递送将以最小的副作用增强治疗效果,其中配体-受体识别是常见的靶向方法。已经报道了各种配体,并且已证明碳水化合物,其是肿瘤细胞膜的关键结构之一,对于细胞选择性结合是有效的。因此,近年来,糖基化介导的靶向癌症的药物纳米载体受到越来越多的关注。这篇综述调查了各种糖基化药物递送系统及其在癌症治疗中的应用。最后还将讨论他们的挑战,机遇和未来前景。

更新日期:2018-02-28
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