Recently, the incidence of allergies is increasing worldwide. Immunoglobulin E (IgE)-mediated hypersensitivity is central to the pathogenesis of asthma, and other allergic diseases. Aster yomena (AY) have been valued for their medical properties including anti-inflammation, anti-pyresis and analgesia properties. In this study, we investigated the anti-allergic effects of AY and isoquercitrin, a functional compound of AY, using a mouse allergy model and cells. In mice with ovalbumin (OVA)-induced allergic rhinitis, oral administration of AY or isoquercitrin reduced secretion of IgE and histamine in the plasma. AY or isoquercitrin regulated both Th1 and Th2 cytokines levels in the plasma. In addition, AY and isoquercitrin showed dose-dependent inhibition of β-hexosaminidase and reduction in mRNA levels of Th2 cytokines in RBL-2H3 cells. Thus, our results demonstrate that AY or isoquercitrin suppresses cytokine production of the allergy response pathway, resulting in prevention or alleviation of allergy symptoms.

近来，过敏症的发生率在世界范围内正在增加。免疫球蛋白E（IgE）介导的超敏性对于哮喘和其他变态反应性疾病的发病机制至关重要。紫苑（AY）因其医学特性包括抗炎，抗热解和镇痛特性而受到重视。在这项研究中，我们使用小鼠过敏模型和细胞研究了AY和AY的功能化合物异槲皮苷的抗过敏作用。在患有卵白蛋白（OVA）诱发的过敏性鼻炎的小鼠中，口服AY或异槲皮苷可降低血浆中IgE和组胺的分泌。AY或异槲皮素可调节血浆中Th1和Th2细胞因子的水平。此外，AY和异槲皮苷显示RBL-2H3细胞中β-己糖胺酶的剂量依赖性抑制和Th2细胞因子mRNA水平的降低。因此，我们的结果证明AY或异槲皮苷抑制变态反应途径的细胞因子产生，导致预防或减轻变态反应症状。