This review intends to provide an overview about the state-of-the art and the latest instrumental developments of tip-enhanced Raman spectroscopy (TERS), particularly addressing selected applications for biological samples. Additionally, a practical guideline of “How to conduct a TERS experiment?” is presented, in order to understand, motivate and practice TERS experiments. Consequently, this review aims to set a basis for further instrumental developments, especially addressing TERS in liquid for prospective applications towards a larger variety of samples.

中文翻译：

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尖端增强拉曼光谱仪的最新仪器开发和生物分析应用

这篇综述旨在提供有关尖端增强拉曼光谱（TERS）的最新技术和最新仪器发展的概述，特别是针对生物样品的某些应用。此外，还有一个实用指南“如何进行TERS实验？” 的目的是为了理解，激发和实践TERS实验。因此，本综述旨在为进一步的仪器开发奠定基础，尤其是针对液体的TERS进行研究，从而有望用于更广泛的样品。