In the early 1990s, a series of randomized trials demonstrated the efficacy of both pharmaceutical aids with behavioral therapy for smoking cessation and treatments for metastatic breast cancer. These treatments were approved by the US Food and Drug Administration and quickly disseminated into clinical practice. A decade later, the population mean survival following a metastatic breast cancer diagnosis had improved 50%, demonstrating the effectiveness of the treatment (1); however, there was no improvement in the proportion of smokers who had successfully quit (2). A critical public health question is how to account for the apparent lack of translation of quitting success into the population.

中文翻译：

---

回复。

在1990年代初期，一系列随机试验证明了药物辅助疗法与行为疗法对戒烟和转移性乳腺癌的疗效。这些治疗方法已获得美国食品和药物管理局的批准，并迅速传播到临床实践中。十年后，转移性乳腺癌诊断后的人群平均存活率提高了50％，证明了该治疗的有效性（1）。但是，成功戒烟的烟民比例没有改善（2）。一个重要的公共卫生问题是如何解决明显缺乏将成功戒烟转化为人口问题的问题。