The integrated stress response system represents an ancillary, extremely conserved signalling pathway present in virtually all eukaryotic cells, which plays an important part in the pathophysiology of several disorders such as cancer and neurodegeneration. However, its role in the cardiovascular system remains largely elusive. Hence, this review aims to acknowledge recent findings regarding the action of the eIF2α kinases in the cardiovascular system and their role in the pathophysiology of related disorders.

中文翻译：

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心血管疾病的综合应激反应系统

整合的应激反应系统代表了几乎所有真核细胞中存在的辅助，极其保守的信号传导途径，它在多种疾病（如癌症和神经退行性疾病）的病理生理学中起着重要的作用。但是，其在心血管系统中的作用仍然难以捉摸。因此，本综述旨在承认有关eIF2α激酶在心血管系统中的作用及其在相关疾病的病理生理学中的作用的最新发现。