Major depressive disorder in some patients leads to a persistent disease with frequent major depressive episodes, and it is not known what underpins this apparently progressive component of the disorder. In The Lancet Psychiatry, Elaine Setiawan and colleagues¹ report the results of a PET imaging study in which they examined microglial activation using the translocator protein (TSPO) ligand, ¹⁸F-FEPPA, after short (<10 years) or long (≥10 years) duration of untreated major depressive disorder. They report that duration of untreated major depressive disorder and genotype were significant predictor variables of TSPO total distribution volume in the prefrontal cortex, anterior cingulate cortex, and insula.

中文翻译：

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小胶质细胞和严重抑郁症：尚不清楚

在某些患者中，重度抑郁症会导致持续的疾病，并伴有严重的重度抑郁发作，目前尚不清楚是什么导致这种明显的进行性疾病。在柳叶刀精神病学，伊莱恩塞蒂亚和同事^1份报告中，他们使用转运蛋白（TSPO）配体，检查小胶质细胞活化的PET成像研究的结果¹⁸ F-FEPPA，短后（<10岁）或长（≥10年）未治疗的严重抑郁症的病程。他们报告说，未经治疗的主要抑郁症的病程和基因型是额叶前额叶皮层，扣带回皮层和岛中TSPO总分布量的重要预测变量。