Abstract

Quindoline is one of the simplest naturally occurring monomeric indoloquinoline alkaloids. Chemists exhibited interest in this compound before it was isolated from a natural source. The different approaches toward the total synthesis of the natural product and its performance in various biological tests are discussed. Aspects related to the isolation of quindoline from different ethnomedicinally relevant plants around the world are also reviewed.

1 Introduction

2 Isolation and Biogenetic Considerations

3 Total Syntheses of Quindoline

3.1 Early Synthetic Studies

3.2 Syntheses from Benzenoids

3.3 Syntheses from Indoles

3.4 Syntheses from Quinolines

4 Biological Activity Studies

5 Conclusions

Quindoline is one of the simplest naturally occurring monomeric indoloquinoline alkaloids. Chemists exhibited interest in this compound before it was isolated from a natural source. The different approaches toward the total synthesis of the natural product and its performance in various biological tests are discussed. Aspects related to the isolation of quindoline from different ethnomedicinally relevant plants around the world are also reviewed.

1 Introduction

2 Isolation and Biogenetic Considerations

3 Total Syntheses of Quindoline

3.1 Early Synthetic Studies

3.2 Syntheses from Benzenoids

3.3 Syntheses from Indoles

3.4 Syntheses from Quinolines

4 Biological Activity Studies

5 Conclusions

中文翻译：

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有价值的吲哚喹啉天然产物和有用的关键中间体喹喔啉的分离，合成和生物活性

摘要

喹啉是最简单的天然吲哚喹啉单体生物碱之一。在从天然来源分离出该化合物之前，化学家对此化合物表现出了兴趣。讨论了天然产物的全合成及其在各种生物学测试中的性能的不同方法。还对与喹啉啉从世界各地不同民族学上相关的植物中分离有关的方面进行了综述。

1引言

2分离和生物遗传学考虑

3种喹喔啉的总合成物

3.1 早期综合研究

3.2 苯类化合物的合成

3.3 吲哚合成

3.4 喹啉的合成

4生物活性研究

5。结论

喹啉是最简单的天然吲哚喹啉单体生物碱之一。在从天然来源分离出该化合物之前，化学家对此化合物表现出了兴趣。讨论了天然产物的全合成及其在各种生物学测试中的性能的不同方法。还对与喹啉啉从世界各地不同民族学上相关的植物中分离有关的方面进行了综述。

1引言

2分离和生物遗传学考虑

3种喹喔啉的总合成物

3.1 早期综合研究

3.2 苯类化合物的合成

3.3 吲哚合成

3.4 喹啉的合成

4生物活性研究

5。结论