In this paper three variants of the electrophoretic method for the determination of thioamides, quinoline derivatives are given: aqueous capillary electrophoresis, micellar electrokinetic capillary chromatography and non-aqueous electrophoresis. CE has some advantages over other approaches: rapid and effective separation, relatively a simple set of tools, and a minimum amount of a sample, and the analysis time is usually short. Non-aqueous capillary electrophoresis (NACE) is an alternative technique to aqueous CE. NACE has been applied for separating some molecules under special circumstances, i.e. when analytes and electrolytes are insoluble or partially soluble in water. Micellar chromatography makes it possible to separate both ionogenic and uncharged components of the sample, due to the introduction of a surfactant into the lead electrolyte. Thus this paper reports successful separation of a mixture of compounds quinoline-2-thione (I) and 8-mercaptoquinoline hydrochloride (II) and the quantitative determination of compounds I–II by capillary zone electrophoresis (CZE) was optimized. CZE provides the sensitive and reproducible estimation of analyte concentration in the range from 0.8–161.2 μg ml⁻¹ for quinoline-2-thione in aqueous medium and 2.19–219.2 μg ml⁻¹ for 8-mercaptoquinoline hydrochloride in non-aqueous medium. The detection limit was 0.4 μg ml⁻¹ for quinoline-2-thione and 1.5 μg ml⁻¹ for 8-mercaptoquinoline hydrochloride respectively.

中文翻译：

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喹啉-2-硫酮和8-巯基喹啉盐酸盐混合物的水和非水电泳和胶束电动毛细管色谱

本文给出了用于测定硫代酰胺，喹啉衍生物的三种电泳方法：水性毛细管电泳，胶束电动毛细管色谱和非水性电泳​​。与其他方法相比，CE具有一些优势：快速有效的分离，相对简单的工具集和最少的样品量，并且分析时间通常很短。非水性毛细管电泳（NACE）是水性CE的替代技术。NACE已用于分离特殊情况下的某些分子，即当分析物和电解质不溶于水或部分溶于水时。由于将表面活性剂引入铅电解质中，胶束色谱使分离样品的电离组分和不带电组分成为可能。因此，本文报道了成功分离出化合物喹啉-2-硫酮（I）和8-巯基喹啉盐酸盐（II）的混合物，并优化了毛细管区带电泳（CZE）对化合物I–II的定量测定。CZE提供分析物浓度的该范围内的敏感和可再现的估计从0.8-161.2微克毫升^-1为在水性介质中和2.19-219.2微克毫升喹啉-2-硫酮^-1为在非水介质中的8 mercaptoquinoline盐酸盐。检出限为0.4μgml ^-1分别用于喹啉-2-硫酮和1.5μgml ^-1的8-巯基喹啉盐酸盐。