The unregulated use of organophosphates (OPs) as pesticides and toxic chemical warfare agents demands their continuous monitoring from a human health perspective. This study describes a fluorescence turn-on sensing assay for the selective quantification of OPs in aqueous medium. Metal complexes of two different Biginelli derivatives were processed in water through a reprecipitation technique. The engineered self-assembly of the pyridyl-2-cobalt complex (L1·Co(II)) was employed to selectively detect malathion while the pyridyl-4-cobalt complex (L2·Co(II)) could estimate azamethiphos fluorimetrically up to a detection limit of 9.2 nM and 11 nM, respectively. Furthermore, the pesticide degradation ability of OPs was assessed using a ³¹P-NMR technique. This new paradigm expands the versatility of Biginelli derivatives as promising sensing platforms via metal complexation which may further be explored for estimation of analytes.

中文翻译：

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Biginelli衍生物的钴配合物作为荧光探针，用于选择性估算和降解水性介质中的有机磷酸盐†

无规使用有机磷酸盐（OPs）作为杀虫剂和有毒化学战剂需要从人类健康的角度对其进行连续监测。这项研究描述了一种荧光开启传感测定法，用于对水性介质中的OP进行选择性定量。通过再沉淀技术在水中加工了两种不同的Biginelli衍生物的金属配合物。吡啶-2-钴配合物（L1·Co（II））的工程自组装被用于选择性检测马拉硫磷，而吡啶基4-钴配合物（L2·Co（II））可以通过荧光法估计氮杂磷。检测限分别为9.2 nM和11 nM。此外，使用³¹评估了OP的农药降解能力。P-NMR技术。这种新的范式扩展了Biginelli衍生物的多功能性，使其成为通过金属络合的有前途的传感平台，可以进一步探索其用于分析物的估算。