Asthma is the most common chronic childhood disease, and its prevalence has increased substantially in recent years.¹ Asthma is a heterogeneous group of diseases, some of which are related to specific immunoglobulin E (IgE) levels, and different endotypes with diverging disease courses have been defined based on molecular mechanisms.² Epigenetic changes in asthma and allergic diseases have recently attracted considerable interest because they might mediate the disease-predisposing and protecting effects of the environment on gene regulation and are implicated in the differentiation of disease-relevant immune cell subtypes.

中文翻译：

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儿童哮喘中嗜酸性粒细胞和其他免疫细胞亚型的表观遗传可塑性

哮喘是最常见的慢性儿童疾病，近年来，其流行率已大大提高。¹哮喘是一组异质性疾病，其中一些与特定的免疫球蛋白E（IgE）水平有关，并且已基于分子机制定义了具有不同疾病进程的不同内型。²哮喘和变态反应性疾病的表观遗传学变化最近引起了广泛的关注，因为它们可能介导疾病对环境的易感性和保护作用对基因调控的作用，并与疾病相关的免疫细胞亚型的分化有关。