Lung cancer is a highly malignant tumor, and targeted delivery of anti‐cancer drugs to deep lung tumor tissue remains a challenge in drug design. Here, it is demonstrated that bone marrow mesenchymal stem cells armed with nanodrugs are highly targeted and mutually destructive with malignant lung cancer cells and successfully eradicate lung tumors tissues. Using this approach, the current clinical dose of anti‐cancer drugs for the treatment of malignant lung tumors can be decreased by more than 100‐fold without triggering immunotoxicity.

中文翻译：

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纳米药物结合的隐匿间充质干细胞相互破坏深肺肿瘤组织

肺癌是一种高度恶性肿瘤，将抗癌药物定向递送至深部肺肿瘤组织仍然是药物设计中的挑战。在此，证明了具有纳米药物的骨髓间充质干细胞具有高度的靶向性，并且与恶性肺癌细胞具有相互破坏性，并成功根除了肺肿瘤组织。使用这种方法，目前用于治疗恶性肺部肿瘤的抗癌药物的临床剂量可以减少100倍以上，而不会触发免疫毒性。