Photoacoustic imaging combines the merits of ultrasound imaging and optical imaging that allows a fascinating imaging paradigm with deeper tissue penetration than optical imaging and higher spatial resolution than ultrasound imaging. Herein, we develop a supramolecular hybrid material composed of graphene oxide (GO) and a pillar[6]arene-based host-guest complex (CP6⊃PyN), which can be used as a ultrasound (US) and photoacoustic (PA) signal nanoamplifier. Triggered by the near-infrared (NIR) light mediated photothermal effect, CO2 nanobubbles are generated on the surface of GO@CP6⊃PyN due to the decomposition of bicarbonate counterions, thus strongly amplifying its US and PA performances. Our study, for the first time, demonstrates enhanced US and PA activity in supramolecular hybrid material on the basis of host-guest chemistry as a photoacoustic nanoplatform.

中文翻译：

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由氧化石墨烯和基于柱[6]芳烃的主客体复合物构建的超分子杂化材料作为超声和光声信号纳米放大器。

光声成像结合了超声成像和光学成像的优点，提供了一种令人着迷的成像范式，具有比光学成像更深的组织穿透力和比超声成像更高的空间分辨率。在此，我们开发了一种由氧化石墨烯（GO）和基于柱[6]芳烃的主客体复合物（CP6⊃PyN）组成的超分子杂化材料，可用作超声（US）和光声（PA）信号纳米放大器。在近红外（NIR）光介导的光热效应的触发下，由于碳酸氢盐抗衡离子的分解，GO@CP6⊃PyN 表面会产生 CO2 纳米气泡，从而强烈增强其 US 和 PA 性能。我们的研究首次证明了基于主客体化学作为光声纳米平台的超分子杂化材料中 US 和 PA 活性的增强。