Eighteen previously undescribed lanostane triterpenes and thirty known analogues were obtained from the fruiting bodies of Ganoderma resinaceum. Resinacein C was isolated from a natural source for the first time. The structures of all the above compounds were elucidated by extensive spectroscopic analysis and comparisons of their spectroscopic data with those reported in the literature. Furthermore, in an in vitro assay, Resinacein C, ganoderic acid Y, lucialdehyde C, 7-oxo-ganoderic acid Z3, 7-oxo-ganoderic acid Z, and lucidadiol showed strong inhibitory effects against α-glucosidase compared with the positive control drug acarbose. The structure-activity relationships of ganoderma triterpenes on α-glucosidase inhibition showed that the C-24/C-25 double bond is necessary for α-glucosidase inhibitory activity. Moreover, the carboxylic acid group at C-26 and the hydroxy group at C-15 play important roles in enhancing inhibitory effects of these triterpenes.

中文翻译：

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来自蘑菇灵芝的羊毛甾烷三萜及其对α-葡萄糖苷酶的抑制活性

从灵芝的子实体中获得了 18 种以前未描述的羊毛脂烷三萜和 30 种已知的类似物。Resinacein C 首次从天然来源中分离出来。所有上述化合物的结构都通过广泛的光谱分析和光谱数据与文献报道的比较来阐明。此外，在体外试验中，与阳性对照药物相比，树脂素 C、灵芝酸 Y、灵芝醛 C、7-氧代灵芝酸 Z3、7-氧代灵芝酸 Z 和灵芝二醇对 α-葡萄糖苷酶显示出强烈的抑制作用阿卡波糖。灵芝三萜对α-葡萄糖苷酶抑制活性的构效关系表明，C-24/C-25双键是α-葡萄糖苷酶抑制活性所必需的。而且，