Abstract We have reported a hybrid polymer composite, consisting of a supramolecular assembly of polydiacetylene (PDA) and phospholipid, that undergoes chromatic and fluorogenic changes after specific interactions with progesterone, the pregnancy hormone. Progesterone was selectively detected among 10 steroids by the mixed polymer of 1,2-dimyristoyl-sn-glycero-3-phosphocholine and PDA at an optimized ratio of 1:9. The triggering effect of progesterone on the membrane mimetic system were investigated using UV–vis, fluorescence, circular dichroism spectroscopy, Raman scattering, dynamic light scattering, transmission electron microscopy, and computational method. These results offer insight into self-assembly disruption and membrane targeting antibiotics as well as PDA-based sensing technology.

中文翻译：

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用于选择性筛选黄体酮的二肉豆蔻酰磷脂酰胆碱/聚二乙炔仿生组件

摘要 我们报道了一种由聚二乙炔 (PDA) 和磷脂的超分子组装体组成的杂化聚合物复合材料，在与孕激素（妊娠激素）发生特异性相互作用后会发生颜色和荧光变化。1,2-dimyristoyl-sn-glycero-3-phosphocholine和PDA的混合聚合物以1:9的最佳比例在10种类固醇中选择性地检测到孕酮。使用紫外-可见光、荧光、圆二色光谱、拉曼散射、动态光散射、透射电子显微镜和计算方法研究了黄体酮对膜模拟系统的触发作用。这些结果提供了对自组装破坏和膜靶向抗生素以及基于 PDA 的传感技术的深入了解。