Efficient CuI/1,10-phen-catalyzed three-component cascade reaction of propargylic alcohols, CO₂, and 2-aminoethanols has been firstly developed for the thermodynamically favourable preparation of 2-oxazolidinones. In the presence of commercially available CuI, 1,10-phen (1,10-phenanthroline) and t-BuOK, the cascade reaction afforded the desired products in good to excellent yields with a broad substrate scope (14 examples). The predicted copper complex Cu₂I₂(phen)₂ in situ formed from CuI and 1,10-phen could activate the triple bond through coordination. The isolation of α-alkylidene cyclic carbonate as the reaction intermediate suggests that the carboxylative cyclization of propargylic alcohol with CO₂, followed by ring-opening reaction, is involved in the one-pot three-component cascade reaction.

丙醇，CO ₂和2-氨基乙醇的高效CuI / 1,10-phen催化的三组分级联反应已被开发出来，用于热力学上有利的2-恶唑烷酮的制备。在可商购获得的CuI，1,10-吩（1,10-菲咯啉）和t - BuOK的存在下，级联反应以良好的产率和优异的产率提供了所需的产物，具有宽的底物范围（14个实施例）。原位预测的铜络合物Cu ₂ I ₂（phen）₂ 由CuI和1,10-phen形成的化合物可以通过配位激活三键。分离作为反应中间体的α-亚烷基环状碳酸酯表明，一锅三组分级联反应涉及炔丙醇与CO ₂的羧基环化，然后开环反应。