In order to fabricate a novel supra-amphiphile with multiple stimulus properties, we developed the strategy of introducing a bi-functional linker to bridge the hydrophilic and hydrophobic building blocks together, by utilizing more than one kind of interaction. We characterized the assembled structure and morphology of the supra-amphiphile using transmission electron microscopy (TEM), dynamic light scattering (DLS) and X-ray diffraction (XRD). ¹H NMR and UV-vis spectroscopy studies revealed that the amphiphile was constructed by the effect of host–guest recognition and a dynamic covalent bond, which could be switched ‘‘on’’ and ‘‘off’’ via UV irradiation and pH variation stimuli, respectively. This responsiveness realized finely controllable self-assembly behaviors of the supra-amphiphile, which was thus able to encapsulate and release the drug model rhodamine B.

中文翻译：

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紫外线和pH响应的超两亲性受组合相互作用驱动，可控制自组装行为†

为了制造具有多种刺激特性的新型超两亲药物，我们开发了一种通过利用一种以上的相互作用引入双功能接头将亲水性和疏水性结构单元桥接在一起的策略。我们使用透射电子显微镜（TEM），动态光散射（DLS）和X射线衍射（XRD）对超两亲分子的组装结构和形态进行了表征。¹ H NMR和UV-Vis光谱法研究表明，两亲物是由主客体识别和动态共价键的作用，这可能“上“”和“被切换””断“”构造通过紫外线照射和pH变化刺激。这种反应性实现了超两亲药物的良好可控自组装行为，因此能够封装和释放药物模型若丹明B。