Many theoretical studies predict that DNA sequencing should be feasible by monitoring the transverse current through a graphene nanoribbon while a DNA molecule translocates through a nanopore in that ribbon. Such a readout would benefit from the special transport properties of graphene, provide ultimate spatial resolution because of the single-atom layer thickness of graphene, and facilitate high-bandwidth measurements. Previous experimental attempts to measure such transverse inplane signals were however dominated by a trivial capacitive response. Here, we explore the feasibility of the approach using a custom-made differential current amplifier that discriminates between the capacitive current signal and the resistive response in the graphene. We fabricate well-defined short and narrow (30 nm × 30 nm) nanoribbons with a 5 nm nanopore in graphene with a high-temperature scanning transmission electron microscope to retain the crystallinity and sensitivity of the graphene. We show that, indeed, resistive modulations can be observed in the graphene current due to DNA translocation through the nanopore, thus demonstrating that DNA sensing with inplane currents in graphene nanostructures is possible. The approach is however exceedingly challenging due to low yields in device fabrication connected to the complex multistep device layout.

中文翻译：

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在具有纳米孔的石墨烯纳米带中利用平面电流信号探测DNA易位。

许多理论研究预测，通过监测穿过石墨烯纳米带的横向电流，同时DNA分子穿过该碳带中的纳米孔进行移位，DNA测序应该是可行的。这样的读数将受益于石墨烯的特殊传输特性，由于石墨烯的单原子层厚度而提供了最终的空间分辨率，并便于进行高带宽测量。然而，先前的测量这样的横向平面内信号的实验尝试主要是琐碎的电容响应。在这里，我们探讨了使用定制的差分电流放大器来区分石墨烯中的电容性电流信号和电阻性响应的方法的可行性。我们使用高温扫描透射电子显微镜在石墨烯中制备了定义明确的短而窄（30 nm×30 nm）的纳米带，纳米带中的纳米孔径为5 nm，以保留石墨烯的结晶度和灵敏度。我们表明，的确，由于通过纳米孔的DNA移位，可以在石墨烯电流中观察到电阻性调节，因此证明了在石墨烯纳米结构中利用面内电流进行DNA感测是可能的。然而，由于连接到复杂的多步器件布局的器件制造中的成品率低，因此该方法极具挑战性。因此证明用石墨烯纳米结构中的平面电流进行DNA感测是可能的。然而，由于连接到复杂的多步器件布局的器件制造中的成品率低，因此该方法极具挑战性。因此证明用石墨烯纳米结构中的平面电流进行DNA感测是可能的。然而，由于连接到复杂的多步器件布局的器件制造中的成品率低，因此该方法极具挑战性。