A concise two-step operation of α-amination of aldehydes and subsequent Friedel–Crafts/Prins-type cyclization towards accessing tetrahydrobenzo[c]phenanthridine and related structures was developed. The reaction displayed a broad substrate scope and good tolerance to a variety of substituents such as different aromatic heterocyclic rings. In addition, the effectiveness of this protocol was also demonstrated in the formal synthesis of homochelidonine and chelamidine.

中文翻译：

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氯胺定生物碱及其衍生物的形式合成†

开发了一个简单的两步醛化α-胺化操作和随后的Friedel-Crafts / Prins型环化反应，以接近四氢苯并[ c ]菲啶和相关结构。该反应显示出广泛的底物范围和对各种取代基如不同的芳族杂环的良好耐受性。此外，该方法的有效性也已在高白屈菜碱和氯胺定的正式合成中得到了证明。