Identification and quantification of an unknown illicit drug (cocaine) from both simulated drug paraphernalia and simulated urine can be achieved via direct analysis in real time (DART) triple quadrupole linear ion trap (QTRAP) mass spectrometry (MS). We describe a novel, hands-on laboratory activity which utilizes the recent DART technology interfaced with a tandem mass spectrometer for the purpose of integrating recent technology into a quantitative analysis course, reinforcing chemical concepts, improving critical thinking and written communication skills, and providing a context for real-life analyses. The hands-on laboratory activity requires students to use good laboratory practice, perform common laboratory calculations, and think critically to perform both qualitative and quantitative analyses and answer real-life forensic questions. Assessments include prelaboratory activity questions, observations during the activity, postlaboratory activity written report, and anonymous summative activity.

中文翻译：

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通过使用实时启用的质谱仪中的直接分析的大学生实验室练习来强化质谱学的概念

可通过实时直接分析（DART）三重四极杆线性离子阱（QTRAP）质谱（MS）对模拟药物用具和模拟尿液中的未知非法药物（可卡因）进行鉴定和定量。我们描述了一种新颖的动手实验室活动，该活动利用最新的DART技术与串联质谱仪相连接，目的是将最新技术集成到定量分析课程中，强化化学概念，改进批判性思维和书面交流技巧，并提供现实生活中的分析环境。动手实验室活动要求学生使用良好的实验室实践，进行常见的实验室计算，并进行批判性思考以进行定性和定量分析，并回答现实生活中的法证问题。