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Separation of Protocatechuic Acid Using Di-(2-ethylhexyl)phosphoric Acid in Isobutyl Acetate, Toluene, and Petroleum Ether
Journal of Chemical & Engineering Data ( IF 2.6 ) Pub Date : 2018-02-22 00:00:00 , DOI: 10.1021/acs.jced.7b00797
Fiona Mary Antony 1 , Kailas Wasewar 1
Affiliation  

Protocatechuic acid has potential pharmacological significance, like antioxidant, antibacterial, and anticancer activity. The extraction of carboxylic acids from dilute aqueous phase is a topic of current interest to researchers. The present equilibrium study deals with the reactive extraction of protocatechuic acid from an aqueous solution by using di-(2-ethylhexyl)phosphoric acid (D2EHPA) in diluents, such as isobutyl acetate (IBA), toluene, and petroleum ether at isothermal conditions (298 ± 1 K). The physical extraction of protocatechuic acid with pure diluents is also carried out. The difference between the physical extraction and the reactive extraction was studied. The effects of acid concentration (0.001–0.01 mol·kg–1), extractant concentration (0.3445–3.1010 mol·kg–1), and type of diluent on the recovery of protocatechuic acid from aqueous solution were determined. KD values were obtained in the ranges of 1.14–4.03, 0.12–0.67, and 0.08–0.48 for D2EHPA in isobutyl acetate, toluene, and petroleum ether, respectively. A maximum KD was obtained as 4.03 using 3.101 mol·kg–1 D2EHPA (in IBA), while 80.11% of the initial protocatechuic acid was extracted. The D2EHPA–IBA system was found to provide the highest distribution coefficient of the three diluents tested. The extraction equilibrium complexation constant, KE, was obtained in the ranges of 5.56–1.17, 0.82–0.20, and 0.49–0.14 for D2EHPA in isobutyl acetate, toluene, and petroleum ether, respectively. The feasibility of the extraction process was evaluated by calculating the minimum solvent to feed ratio and the number of theoretical stages of the extraction column. The number of theoretical stages for the D2EHPA–IBA system was calculated to be 3, and it was 1 for the D2EHPA–toluene and D2EHPA–petroleum ether systems.

中文翻译:

在乙酸异丁酯,甲苯和石油醚中使用二(2-乙基己基)磷酸分离原儿茶酸

原儿茶酸具有潜在的药理学意义,例如抗氧化剂,抗菌剂和抗癌活性。从稀水相中提取羧酸是研究人员当前感兴趣的话题。本平衡研究涉及通过在等温条件下在稀释剂(例如乙酸异丁酯(IBA),甲苯和石油醚)中使用二-(2-乙基己基)磷酸(D2EHPA)从水溶液中反应萃取原儿茶酸( 298±1 K)。还可以使用纯稀释剂对原儿茶酸进行物理萃取。研究了物理萃取和反应萃取的区别。酸浓度(0.001–0.01 mol·kg –1),萃取剂浓度(0.3445–3.1010 mol·kg –1)的影响),并确定从水溶液中回收原儿茶酸的稀释剂类型。在乙酸异丁酯,甲苯和石油醚中,D2EHPA的K D值分别在1.14–4.03、0.12–0.67和0.08–0.48范围内。使用3.101 mol·kg –1 D2EHPA(在IBA中)获得的最大K D为4.03 ,同时提取了原始原儿茶酸的80.11%。发现D2EHPA–IBA系统在所测试的三种稀释剂中具有最高的分配系数。萃取平衡络合常数K E在乙酸异丁酯,甲苯和石油醚中的D2EHPA分别获得5.56-1.17、0.82-0.20和0.49-0.14的范围。通过计算最小溶剂进料比和萃取塔的理论级数来评估萃取过程的可行性。D2EHPA–IBA系统的理论级数经计算为3,而D2EHPA–甲苯和D2EHPA–石油醚系统为1。
更新日期:2018-02-22
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