Aneuploidy, or unbalanced chromosome number, is a hallmark of cancer. Recently established model systems revealed that aneuploidy affects many aspects of cellular physiology, among them sphingolipid metabolism. The new finding that the proliferation of aneuploid cells depends on sphingolipid homeostasis offers an appealing opportunity for cancer treatment.

中文翻译：

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鞘脂周转改变非整倍体细胞的命运

非整倍性或不平衡的染色体数是癌症的标志。最近建立的模型系统揭示非整倍性影响细胞生理学的许多方面，其中包括鞘脂代谢。非整倍体细胞增殖取决于鞘脂稳态的新发现为癌症治疗提供了诱人的机会。