Oxazoline-containing ligands have been widely employed in numerous asymmetric catalytic reactions. Pyridine-oxazoline-type ligands, a class of hybrid ligands, were designed earlier than bisoxazoline and phosphine-oxazoline ligands; however, their unique properties have only been discovered recently. Pyridine-oxazoline-type chiral ligands are rapidly becoming popular for use in asymmetric catalysis, especially for several new and efficient asymmetric methodologies. Several types of challenging asymmetric reactions have been discovered recently using pyridine-oxazoline-type ligands showing their special properties and potential for future application in a wide range of new catalytic methodologies. This review provides an overview of this field, with the aim of highlighting both ligand design and synthetic methodology development.

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吡啶-恶唑啉作为不对称催化的手性配体的复兴

含恶唑啉的配体已广泛用于许多不对称催化反应中。吡啶-恶唑啉型配体（一种杂合配体）的设计要早于双恶唑啉和膦-恶唑啉配体。但是，它们的独特属性只是最近才被发现。吡啶-恶唑啉型手性配体正迅速用于不对称催化，特别是用于几种新的有效的不对称方法。最近，使用吡啶-恶唑啉型配体发现了几种类型的具有挑战性的不对称反应，这些配体显示出它们的特殊性能，并有望在各种新的催化方法中得到未来应用。这篇综述提供了该领域的概述，旨在强调配体设计和合成方法学的发展。