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MSN‐on‐a‐Chip: Cell‐Based Screenings Made Possible on a Small‐Molecule Microarray of Native Natural Products
ChemBioChem ( IF 3.2 ) Pub Date : 2018-04-17 , DOI: 10.1002/cbic.201800101
Bo Peng 1 , Changmin Yu 2 , Shubo Du 1 , Si S. Liew 1 , Xin Mao 1 , Peiyan Yuan 1 , Zhenkun Na 1 , Shao Q. Yao 1
Affiliation  

Natural product microarrays: A new microarray platform capable of high‐throughput, high‐content cell‐based screening of natural products without compound modification (or direct immobilization) has been developed. (+)‐Usniacin was found to possess synergistic inhibitory properties similar to those of the approved drug olaparib in BRCA1‐knockdown cancer cells.
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中文翻译:

芯片上的MSN:在天然天然产物的小分子微阵列上进行基于细胞的筛选成为可能

天然产物微阵列:已开发出一种新的微阵列平台,该平台能够对天然产物进行高通量,高含量的基于细胞的筛选,而无需进行化合物修饰(或直接固定)。(+)‐ Usniacin被发现具有与BRCA1基因敲低癌细胞中的已批准药物olaparib相似的协同抑制特性。
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更新日期:2018-04-17
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