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Isoflavone-enriched soybean (Glycine max) leaves prevents ovariectomy-induced obesity by enhancing fatty acid oxidation
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2018-02-20 , DOI: 10.1016/j.jff.2018.02.014
Cheng-liang Xie , Sang Soo Kang , Kye Man Cho , Ki Hun Park , Dong Hoon Lee

Dietary isoflavones have been gaining increased interest in the field of functional foods due to their ability to ameliorate several postmenopausal symptoms. Using ovariectomized (OVX) rats supplemented with isoflavone-enriched soybean leaves (IESLs), we investigated the effect of dietary isoflavones on menopausal-associated obesity. Oral administration of IESLs significantly reduced OVX-induced weight gain and visceral fat mass. Additionally, IESLs significantly ameliorated OVX-induced hepatic steatosis as reflected by decreased triacylglycerol accumulation in the liver and decreased serum alanine transaminase and aspartate aminotransferase levels. These anti-obesity effects of IESLs were confirmed to be due to enhanced fatty acid oxidation via up-regulation of peroxisome proliferator activated receptor alpha, peroxisomal acyl-coenzyme A oxidase 1, and carnitine palmitoyltransferase 1a mRNA expression. These results demonstrate that IESLs may be an effective functional food-based approach to protect against menopause-associated obesity.



中文翻译:

富含异黄酮的大豆(甘氨酸最大)叶防止通过提高脂肪酸氧化卵巢切除引发的肥胖

饮食中的异黄酮由于能够缓解某些绝经后症状,因此在功能性食品领域已引起越来越多的关注。使用卵巢切除的(OVX)大鼠补充富含异黄酮的大豆叶(IESLs),我们研究了饮食中的异黄酮对绝经相关肥胖的影响。口服IESL可以显着降低OVX引起的体重增加和内脏脂肪量。此外,IESLs明显改善了OVX引起的肝脂肪变性,这反映为肝脏中三酰甘油的积累减少以及血清丙氨酸转氨酶和天冬氨酸转氨酶水平的降低。IESL的这些抗肥胖作用已被证实是由于过氧化物酶体增殖物激活受体α的上调导致脂肪酸氧化增强所致,过氧化物酶体酰基辅酶A氧化酶1和肉碱棕榈酰转移酶1a mRNA表达。这些结果表明,IESLs可能是一种有效的基于食物的功能性方法,可预防更年期相关的肥胖症。

更新日期:2018-02-20
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