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Probiotic plus low-calorie diet increase gene expression of Toll-like receptor 2 and FOXP3 in overweight and obese participants
Journal of Functional Foods ( IF 5.6 ) Pub Date : 2018-02-20 , DOI: 10.1016/j.jff.2018.02.013
Bahareh Yazdani , Farzad Shidfar , Eisa Salehi , Fahimeh Baghbani-arani , Elham Razmpoosh , Zatollah Asemi , Elhameh Cheshmazar , Mitra Zarrati

We evaluated the effects of probiotic supplementation with a low-calorie diet on the gene expression of mediators of the immune system among overweight and obese individuals; participants were randomly divided into three groups of 25 each: group 1 consumed conventional yogurt with a low-calorie diet (CLCD); group 2 consumed probiotic yogurt with a low-calorie diet (PLCD) and group 3 consumed probiotic yogurt without a low-calorie diet (PWLCD) for 8 weeks. Probiotic yogurt contained Lactobacillus acidophilus LA5, Lactobacillus casei DN001, Bifidobacterium lactis Bb12 and Streptococcus thermophiles (108 CFU/mL each). Quantitative results of RT-PCR demonstrated that there was an increase in the gene expression of toll like receptor 2(TLR2) in PLCD group compared to CLCD and PWLCD groups (2.7 ± 2.8 vs. 0.9 ± 0.8, 1.9 ± 1.6, respectively, P = 0.001) as well as an increase in FOXP3 gene in PLCD group compared to the other groups (11.2 ± 6.7 vs. 6 ± 2.5, 6.3 ± 1.9, respectively, P < 0.001). Our study demonstrated that the 8-week consumption of PLCD among overweight and obese individuals resulted in a significant up-regulation in the expression of the TLR2.



中文翻译:

益生菌加低热量饮食可增加超重和肥胖参与者中Toll样受体2和FOXP3的基因表达

我们评估了补充低热量饮食的益生菌对超重和肥胖个体免疫系统介体基因表达的影响。参与者被随机分为三组,每组25个:第1组食用低热量饮食(CLCD)的常规酸奶;第2组食用低热量饮食(PLCD)的益生菌酸奶,第3组食用无低热量饮食(PWLCD)的益生菌酸奶,持续8周。益生菌酸奶包含嗜酸乳杆菌LA5,干酪乳杆菌DN001,乳酸双歧杆菌Bb12和嗜热链球菌(各10 8 CFU / mL)RT-PCR的定量结果表明,与CLCD和PWLCD组相比,PLCD组中Toll样受体2(TLR2)的基因表达有所增加(分别为2.7±2.8和0.9±0.8、1.9±1.6,P = 0.001)以及PLCD组的FOXP3基因增加(与其他组相比)(分别为11.2±6.7与6±2.5、6.3±1.9,P <0.001)。我们的研究表明,超重和肥胖个体中PLCD消耗8周会导致TLR2表达的显着上调。

更新日期:2018-02-20
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