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Anti-aging potential of tree nuts with a focus on the phytochemical composition, molecular mechanisms and thermal stability of major bioactive compounds
Food & Function ( IF 6.1 ) Pub Date : 2018-02-21 00:00:00 , DOI: 10.1039/c7fo01967j Marius Emil Rusu 1, 2, 3, 4, 5 , Ana-Maria Gheldiu 2, 3, 4, 5, 6 , Andrei Mocan 2, 3, 4, 5, 6 , Laurian Vlase 1, 2, 3, 4, 5 , Daniela-Saveta Popa 2, 3, 4, 5, 7
Food & Function ( IF 6.1 ) Pub Date : 2018-02-21 00:00:00 , DOI: 10.1039/c7fo01967j Marius Emil Rusu 1, 2, 3, 4, 5 , Ana-Maria Gheldiu 2, 3, 4, 5, 6 , Andrei Mocan 2, 3, 4, 5, 6 , Laurian Vlase 1, 2, 3, 4, 5 , Daniela-Saveta Popa 2, 3, 4, 5, 7
Affiliation
Tree nuts, complete functional foods, contain macro- and micronutrients of high biological value. These bioactive compounds have a synergistic effect in preventing and delaying many age-related pathologies (e.g. cardiovascular diseases, stroke, type 2 diabetes mellitus, certain types of cancer, and several neurodegenerative diseases). Tree nuts are low in carbohydrates, but they abound in healthy fatty acids, in optimal proportion for a good plasma lipid profile, and are a good source of proteins, rich in proteinogenic amino acids. They contain significant amounts of vitamin E, minerals, polyphenols, and phytosterols. Polyphenols, which are powerful phytochemicals, act as direct and indirect antioxidants, reduce the inflammatory response, improve proteostasis and mitochondrial biogenesis, modulate many cell signaling pathways, have a major role in cytoprotection, are Nrf2/ARE activators, down-regulate the NFκB system, promote anticancer potential, and prevent cell senescence. Some of them have senolytic effects, interfere in specific cell signaling pathways modulated by caloric restriction, and protect against UV radiation and photoaging. Moreover, tree nuts are good prebiotics and improve gut microbiota. The stability of polyphenolic compounds and their antioxidant activity can be influenced by cooking techniques, temperature of storage, and post-harvest processing methods. The consumption of tree nuts has been scientifically proven to improve lifespan and healthspan and should be a part of a healthy diet in the elderly.
中文翻译:
坚果的抗衰老潜力,重点在于主要生物活性化合物的植物化学组成,分子机理和热稳定性
坚果是一种功能齐全的食品,其中含有具有很高生物学价值的大量和微量营养素。这些生物活性化合物在预防和延缓许多与年龄有关的疾病(例如,心血管疾病,中风,2型糖尿病,某些类型的癌症以及几种神经退行性疾病)。坚果中的碳水化合物含量低,但它们富含健康的脂肪酸,以最佳比例存在,具有良好的血浆脂质特性,并且是富含蛋白质的氨基酸的良好蛋白质来源。它们含有大量的维生素E,矿物质,多酚和植物甾醇。多酚是强大的植物化学物质,可作为直接和间接的抗氧化剂,减少炎症反应,改善蛋白稳态和线粒体生物发生,调节许多细胞信号通路,在细胞保护中起主要作用,是Nrf2 / ARE激活剂,下调NFκB系统,增强抗癌潜力,并防止细胞衰老。其中一些具有衰老作用,干扰受热量限制调节的特定细胞信号传导途径,并防止紫外线辐射和光老化。此外,坚果是很好的益生元,可以改善肠道菌群。多酚化合物的稳定性及其抗氧化活性可能会受到蒸煮技术,储存温度和收获后加工方法的影响。食用坚果已被科学证明可以改善寿命和健康状况,应成为老年人健康饮食的一部分。
更新日期:2018-02-21
中文翻译:
坚果的抗衰老潜力,重点在于主要生物活性化合物的植物化学组成,分子机理和热稳定性
坚果是一种功能齐全的食品,其中含有具有很高生物学价值的大量和微量营养素。这些生物活性化合物在预防和延缓许多与年龄有关的疾病(例如,心血管疾病,中风,2型糖尿病,某些类型的癌症以及几种神经退行性疾病)。坚果中的碳水化合物含量低,但它们富含健康的脂肪酸,以最佳比例存在,具有良好的血浆脂质特性,并且是富含蛋白质的氨基酸的良好蛋白质来源。它们含有大量的维生素E,矿物质,多酚和植物甾醇。多酚是强大的植物化学物质,可作为直接和间接的抗氧化剂,减少炎症反应,改善蛋白稳态和线粒体生物发生,调节许多细胞信号通路,在细胞保护中起主要作用,是Nrf2 / ARE激活剂,下调NFκB系统,增强抗癌潜力,并防止细胞衰老。其中一些具有衰老作用,干扰受热量限制调节的特定细胞信号传导途径,并防止紫外线辐射和光老化。此外,坚果是很好的益生元,可以改善肠道菌群。多酚化合物的稳定性及其抗氧化活性可能会受到蒸煮技术,储存温度和收获后加工方法的影响。食用坚果已被科学证明可以改善寿命和健康状况,应成为老年人健康饮食的一部分。