Polymeric materials responsive to endogenous and exogenous stimuli promise to overcome multitude of barriers faced during systemic delivery of therapeutic nucleic acids. In article number 1701070, David Oupický and co‐workers survey successful examples of enhanced nucleic acid delivery using polymers that respond to changes in pH, redox state, enzyme levels, hypoxia, reactive oxygen species, light, ultrasound, and hyperthermia.

中文翻译：

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治疗性核酸：用于系统递送核酸的刺激刺激性聚合材料的研究进展（Adv。Healthcare Mater。4/2018）

响应于内源性和外源性刺激的聚合材料有望克服在治疗性核酸全身性递送过程中面临的众多障碍。DavidOupický和同事在文章编号1701070中调查了成功的例子，这些例子使用了可响应pH值，氧化还原状态，酶水平，低氧，活性氧，光，超声和热疗变化的聚合物来增强核酸的递送。